Autophagy in Cardiac Plasticity and Disease
نویسندگان
چکیده
منابع مشابه
Crosstalk Between Autophagy and Apoptosis in Heart Disease Autophagy in Ischemic Heart Disease Cardiomyocyte Autophagy in Load-Induced Heart Disease Autophagy and Atherosclerosis Molecular Mechanisms of Autophagy
Autophagy is a cell survival mechanism that involves degradation and recycling of cytoplasmic components, such as long-lived proteins and organelles. In addition, autophagy mediates cell death under specific circumstances. Apoptosis, a form of programmed cell death, has been well characterized, and the molecular events involved in apoptotic death are well understood. Damaged cardiomyocytes that...
متن کاملCardiac plasticity.
From the Donald W. Reynolds Cardiovascular Clinical Research Center ( J.A.H., E.N.O.); and the Departments of Internal Medicine (Cardiology) ( J.A.H.) and Molecular Biology ( J.A.H., E.N.O.), University of Texas Southwestern Medical Center, Dallas. Address reprint requests to Dr. Hill at the Division of Cardiology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., NB11.20...
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Autophagy is necessary for the degradation of long-lasting proteins and nonfunctional organelles, and is activated to promote cellular survival. However, overactivation of autophagy may deplete essential molecules and organelles responsible for cellular survival. Lifelong calorie restriction by 40% has been shown to increase the cardiac expression of autophagic markers, which suggests that it m...
متن کاملAutophagy in myocardial differentiation and cardiac development.
Autophagy represents an important biological process that contributes to cellular homeostasis. It is induced when the cell experiences stress, including nutrient and energy deprivation. For instance, the absence of nutrients and growth factors induces autophagy within minutes.1 Autophagy functions to protect cells against potential damage in association with exposure to stress, and thereby help...
متن کاملAutophagy and p62 in cardiac proteinopathy.
RATIONALE Recent studies suggest an important role of autophagy in protection against αB-crystallin-based (CryAB(R120G)) desmin-related cardiomyopathies (DRC), but this has not been demonstrated in a different model of cardiac proteinopathy. Mechanisms underlying the response of cardiomyocytes to proteotoxic stress remain incompletely understood. OBJECTIVE Our first objective was to determine...
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ژورنال
عنوان ژورنال: Pediatric Cardiology
سال: 2011
ISSN: 0172-0643,1432-1971
DOI: 10.1007/s00246-010-9883-6